We often have good quality, healthy embryos, but in spite of this we are unable to obtain a viable pregnancy (cases of repeated implantation failure), or we obtain a pregnancy but it does not progress (cases of recurrent miscarriage). Although not always the case, there are often underlying immune problems which prevent the mother from accepting the embryo.
Immunology is one of the physiological pillars essential to achieving a pregnancy, as the success of a pregnancy depends on correct immune balance.
Pregnancy is a challenge and an immunological paradox for the mother, as her immune system must allow a semiallogeneic embryo to implant (an embryo that shares 50% of her genetic material) or even an allogeneic embryo to implant (100% of the embryo’s genetic material is different from the mother’s). According to the laws of transplantation immunology, the mother should reject this different genetic material. However, under normal conditions embryo implantation is tolerated.